Boss

Template:D2 NavMonsters !width=150|Champion !width=150|Unique !width=150|Super Unique !width=128|Boss |}

Always spawn in the same location. Only [[D2 Griswold|Template:D2 Unique bold]], [[D2 Radament|Template:D2 Unique bold]], and [[D2 Nihlathak|Template:D2 Unique bold]] receive randomly selected Unique bonuses in Nightmare and Hell (Putrid Defilers are treated as normal Unique monsters). AI of boss cannot be switched but that of any minions can (although Putrid Defiler minions are also classed as bosses). Ignores Target Defense does not apply to boss but does apply to any minions. -% Target Defense from items is only 50% effective against boss but still 100% effective against minions. -% Enhanced Defense from Cloak of Shadows is not applied. Life lost to Crushing Blow is halved (so 1/8 of current life when applied by a melee attack and 1/16 when applied by a ranged attack).

• [[D2 Blood Raven|Template:D2 Unique bold]]
• [[D2 Griswold|Template:D2 Unique bold]]
• [[D2 Radament|Template:D2 Unique bold]]
• [[D2 Summoner|Template:D2 Unique bold]]
• [[D2 Izual|Template:D2 Unique bold]]
• Putrid Defiler
• [[D2 Nihlathak|Template:D2 Unique bold]]
• [[D2 Uber Izual|Uber Template:D2 Unique bold]]

Prime Evil

• Holy Freeze does not slow or apply its cold radial damage.
• Apply 200% damage to hirelings and 400% damage to pets.
• Hirelings only apply 50% damage in Normal, 35% damage in Nightmare and 25% damage in Hell.

Act boss

• [[D2 Andariel|Template:D2 Unique bold]]
• [[D2 Duriel|Template:D2 Unique bold]]
• [[D2 Mephisto|Template:D2 Unique bold]]
• [[D2 Diablo|Template:D2 Unique bold]]
• [[D2 Baal|Template:D2 Unique bold]]
  • [[D2 Baal clone|Template:D2 Unique bold clone]]

World event

• [[D2 Diablo clone|Template:D2 Unique bold clone]]

Pandemonium event

• [[D2 Lilith|Template:D2 Unique bold]]
• [[D2 Uber Duriel|Uber Template:D2 Unique bold]]
• [[D2 Uber Mephisto|Uber Template:D2 Unique bold]]
• [[D2 Uber Diablo|Uber Template:D2 Unique bold]]
• [[D2 Uber Baal|Uber Template:D2 Unique bold]]

• Prevent Monster Heal not applied.