Boss

• Always spawn in the same location.
• Only Template:D2 Unique bold, Template:D2 Unique bold and Template:D2 Unique bold receive randomly selected Unique bonuses in Nightmare and Hell (Putrid Defilers are treated as normal Unique monsters).
• -% Defense from Cloak of Shadows is not applied.
• Ignores Target Defense only applies to minions.
• -% Target Defense is only 50% effective, but still 100% effective against minions.
• Freeze length chills instead; only minions can be frozen.
• Stun length does not apply.
• Effects altering AI cannot be applied directly, but can affect minions (although Putrid Defiler minions are also classed as bosses).
• Life lost to Crushing Blow is halved (so 1/8 of current base life when applied by a melee attack and 1/16 when applied by a ranged attack).
• Slow Missiles does not apply.

Prime Evil

• Holy Freeze does not slow or apply its radial cold damage.
• Hirelings only apply 50% damage in Normal, 35% damage in Nightmare and 25% damage in Hell.
• Apply 200% damage to hirelings and 400% damage to pets.

Act boss

• [[D2 Andariel|Template:D2 Unique bold]]
• [[D2 Duriel|Template:D2 Unique bold]]
• [[D2 Mephisto|Template:D2 Unique bold]]
• [[D2 Diablo|Template:D2 Unique bold]]
• [[D2 Baal|Template:D2 Unique bold]]

World event

• [[D2 Diablo clone|Template:D2 Unique bold clone]]

Pandemonium event

• [[D2 Lilith|Template:D2 Unique bold]]
• [[D2 Uber Duriel|Uber Template:D2 Unique bold]]
• [[D2 Uber Mephisto|Uber Template:D2 Unique bold]]
• [[D2 Uber Diablo|Uber Template:D2 Unique bold]]
• [[D2 Uber Baal|Uber Template:D2 Unique bold]]

• Prevent Monster Heal not applied.